12-O-tetradecanoylphorbol-13-acetate and the induction of prostaglandin E2 generation by human keratinocytes: a re-evaluation.

12-O-Tetradecanoylphorbol-13-acetate (TPA) induces prostaglandin E 2 (PGE 2 ) synthesis in mouse keratinocytes and is associated with the induction of keratinocyte proliferation as well as accelerated differentiation. In human keratinocytes, TPA has been reported not to induce the release of either 3 H-labeled arachidonic acid or 3 H-labeled prostaglandins, even though cell differentiation is stimulated