Efficient aldol condensation in aqueous biphasic system under microfluidic conditions

A microfluidic system was applied to aldol reaction in aqueous biphasic medium. Advantageous aspects of microfluidic conditions, that is, efficient mixing, fast heat transfer, and residence time control led to the high-yielding reaction of acetone enolate with even α-proton-containing aldehydes in biphasic aqueous-acetone system, by minimizing the formation of self-condensation products.