Simian Virus 40 Contaminated Vaccine: Correlation with Present Prevalence of Lymphomas

Simian Virus 40 (SV40) is a DNA virus associated with selected human cancers at varying frequencies. Recently, SV40 has been numerously implicated of having a role in lymphoma genesis. This review evaluated the correlation of past SV40 contaminated vaccine and present SV40 prevalence in lymphoproliferative disorders, using epidemiological and laboratory research on present accusations on SV40 as a lymphoma virus, sustaining that present lymphoma prevalence is not caused by early contaminated vaccine because environmental and natural factors are also implicated. It suggested in vitro infection of human lymphocyte cells with SV40 virus to verify productive infection which serve as a model for studying interactions of SV40 with human lymphocytes and understand the possibility of its playing a role in lymphoproliferative disorders.