Unexpected Enhancement in Antibacterial Activity of N-Halamine Polymers from Spheres to Fibers

Preventing bacterial infections is a main focus of medical care. Antibacterial agents with broad and excellent disinfection capability against pathogenic bacteria are in fact urgently required. Herein, a novel strategy for the development of N-halamine polymers from spheres to fibers using a combined copolymerization-electrospinning-chlorination technique was reported, allowing fight against bacterial pathogen. Optimizing the process conditions, e.g., comonomer molar ratio, concentration of electrospinning solution, chlorination order, and chlorination period, resulted in the formation of N-halamine fibers with controllable morphology. N-Halamine polymers were tested against two common bacterial pathogens, Escherichia coli and Staphylococcus aureus, and were found to be extremely potent against both bacteria, suggesting that they possess powerful sterilizing properties. Remarkably, compared with those with sphere morphology, N-halamine fibers show unexpected enhancement toward both pathogens possibly beca...