Its Mechanism and Potential Role in Carcinogenesis

17.7% of cases and was associated with reduced expression levels. These results suggest that DUSP6 is a growth suppressor whose inactivation could promote the progression of lung cancer. We have here identified an important factor involved in carcinogenesis through a comprehensive search for downstream targets of oncogenic KRAS. (Am J Pathol 2009, 175:867–881; DOI: 10.2353/ajpath.2009.080489)