Clinical Characteristics of Coronavirus Disease 2019 Patients with Maintenance Hemodialysis/ 需维持性血液透析患者合并新型冠状病毒肺炎的临床表现

Objective To analyze the clinical characteristics of the coronavirus disease 2019 ( COVID-19) patients with maintenance hemodialysis ( MHD) ． Methods A retrospective analysis was performed on 78 COVID-19 patients with MHD admitted to the Fifth Hospital of Wuhan in Wuhan，from February 13，2020 to March 3，2020． They were divided into critical group ( n = 12) and general group ( n = 66) according to the severity of the disease，and patients were followed up to the clinical endpoint． The observation indicators included total blood count，lymphocyte count，C － re- active protein ( CＲP) ，procalcitonin ( PCT) ，B-type natriuretic peptide ( BNP) ，chest CT and nucleic acid detection． Results 82 1% MHD patients combined with COVID － 19 had atypical or no clinical symptoms． The positive rate ( 51 2% ) of nucleic acid detection was significantly lower compared with chest CT results ( 71 7% ) ( P ＜ 0 05) ． Com- pared with the general group，the CＲP ［( 33 53 ± 10 28) mg /L vs． ( 157 46 ± 45 57) mg /L］，PCT ［( 0 256 ± 0 035) μg /L vs． ( 1 362 ± 0 874) μg /L］and BNP ［( 2 838 7 ± 359 6) ng /L vs． ( 25 007 6 ± 2 355 9) ng /L］were significantly higher in the critical group;and the lymphocyte count ［( 0 95 ± 0 87) × 109·L －1 vs． ( 0 35 ± 0 08) × 109·L－1］ was extremely lower in the critical group ( P ＜ 0 01) ． Conclusion MHD patients combined with COVID-19 have mild clinical symptoms，and are associated with a higher risk of mortality． Adequate hemodialysis can improves prognosis．