FAP-Associated Desmoid Tumours
2010
Desmoid tumours are rare and may occur spontaneously or in association with FAP (familial adenomatous polyposis). In both settings trauma as a trigger for growth initiation has been postulated. They differ in their predominant localisation, whereas differences in biological behaviour or response to therapeutic approaches have yet to be delineated. In all cases the tumour is frequently not recognized and treatment options are not being weighed thoroughly. Frequent debulking procedures lead to more aggressive growth and high morbidity and mortality. For the majority of desmoid tumours a less aggressive therapeutic approach may be more benefical in the long-term results, especially for desmoids occurring in the mesentery of FAP patients, that have already been subjected to colectomy.
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