The significance of methionine cycle enzymes in plant virus infections

Both biotic and abiotic stresses cause changes in the activities of plant methionine cycle (MTC) enzymes. These changes contribute to the ability of the plant to manage stress. On the other hand, viruses utilize MTC enzymes to promote infection. Here, we review the growing but still limited knowledge of the interactions between plant viral proteins and MTC enzymes. Virus-induced changes in S -adenosyl methionine synthetase and S -adenosyl homocysteine hydrolase activities debilitate transcriptional and post-transcriptional RNA silencing and affect antiviral defense reactions connected to ethylene and polyamine biosynthesis pathways. Viral perturbations of host methionine homeostasis couple trans -sulfuration and gluthathione biosynthesis pathways to MTC functions. Large multiprotein complexes, which contain viral proteins and MTC enzymes, may represent metabolons assembled for specific viral functions or host defense responses. Proper understanding of the MTC-associated metabolic and regulatory interactions will reveal those with potential to create virus resistance in plants.