Effects of leukotrienes on bronchial secretions

: Leukotrienes have multiple effects on the bronchi (inflammation, bronchoconstriction, increased vascular permeability...). They are also directly involved in regulating the composition of bronchial secretions. In vitro studies in animals and in man have demonstrated that sulphidopeptide leukotrienes stimulate active secretion of chloride by airway epithelial cells, an effect that should favor hydration of bronchial secretions. In addition, sulphidopeptide leukotrienes are powerful stimulants for mucin glycoprotein secretion. This effect is limited, at least in vitro, by inhibitors of the lipoxygenase pathway. These results underline the need for clinical studies to better define the role of leukotrienes in bronchial hypersecretion and to evaluate the effect of anti-leukotriene agents.