Plasma Brain Natriuretic Peptide Levels in Rheumatic Mitral Stenosis and Regurge

Rheumatic heart disease (RHD) is still an important cause of heart failure in developing countries. Although there are a few studies of Brain natriuretic peptide (BNP) levels in patients with mitral stenosis and regurge, to our knowledge, no previous study has systematically assessed the levels of BNP and the factors stimulating BNP secretion in rheumatic heart disease.BNP is a cardiac hormone secreted from the ventricular myocardium as a response to ventricular volume expansion and pressure overload.The objective of this work was to measure the leveles of BNP in patients with rheumatic mitral stenosis and regurge and its clinical and echocardiographic correlation. We studied 45 patients, 15 patients with rheumatic mitral stenosis, 15 rheumatic mitral regurge and 15 healthy subjects as a control group. The results of this study showed that there was statistically significant difference between the BNP plasma level in mitral stenosis and regurge patients, and group control subjects. Also there was positive correlation between the plasma level of BNP and the severity of MVD, left ventricular end systolic dimension, left ventricular end diastolic dimension, left atrial size and that there was reverse significance correlation between the plasma level of BNP and left ventricular ejection fraction, but there was no correlation with the gender of the subjects or the presence or absence of pulmonary hypertension. The conclusion from our results suggested that in rheumatic, chronic MVD, BNP activation is present and biologically active and reflects essentially the hemodynamic, ventricular and atrial consequences. Thus, BNP emerge as a biomarker of severity of MVD consequence. (Yasser Elsayed Mohammed, Abdel Raouf Abdel Raouf Mahomud and Ahmed Fathy Abd El Aziz. Plasma Brain Natriuretic Peptide Levels in Rheumatic Mitral Stenosis and Regurge. Researcher. 2013;5(3):52-59). (ISSN: 1553-9865). http://www.sciencepub.net. 8