Amplitude division aperture synthesis optical coherence tomography

In optical coherence tomography (OCT), state-of-the-art aberration correction methods require the light signal to be stable in phase over the full-field data acquisition period, which is difficult to maintain during dynamic cellular processes in vivo. Here we demonstrated that any optical aberrations in the path length difference (OPD) domain can be corrected without the need for phase stability based on the assumption of maximum strength. Amplitude division aperture synthesis OCT (ADAS-OCT) compensates aberrations in the path length difference (OPD) domain by physical aperture synthesis and simultaneously data acquisition from subapertures, eliminating the phase stability requirement. We demonstrate restoration of point-spread function in ADAS-OCT using tissue phantoms.