Ultrastructure of clear cell carcinoma of the vagina and the cervix. Report of a case with unusual ultrastructural findings

The ultrastructural study of a primary adenocarcinoma of the vagina with no history of maternal medication is described. A 27 year old girl was found to have a clear cell adenocarcinoma. The striking feature was the presence of vesicular aggregates in a large proportion of the nuclei. The aggregates consisted of vesicles from 600 to 850 A in diameter and characterized by a single smooth membrane. The aggregates were located in the nucleoplasm the perinuclear cytoplasm or between the 2 membranes of the nuclear envelope.