Process Improvement on the Synthesis of Zoledronate Sodium

Zoledronate sodium in total yield of 60.0% and purity of 99.8% was synthesized by the reaction of condensation and hydrolysis from imidazol-1-yl-acetic acid hydrochloride in ionic liquids{BF4}.The structure was characterized by 1H NMR and IR.BF4 can be easily recycled and reused.