Remarkable Memory-Enhancing Effects of Pregnenolone Sulfate with Pheromone-Like Sensitivity

When it is desired to improve nervous system function, such as enhancing suboptimal learning or accelerating repair of damage as a result of disease, injury, or aging, it is necessary to facilitate adaptive coupling among relevant functional processes by relieving rate-limiting constrictions in mutually shaping interactions among intracellular, intercellular, and extracellular components of the system (1). My colleagues and I have performed many experiments over the years that have shown that some of the steroids found normally in blood have facilitatory effects on aspects of nervous function (e.g., 2–5). Virtually all aspects of relevant published work have been thoroughly reviewed (6,7). Herein I confine my comments only to the remarkable enhancement by pregnenolone sulfate (PREGS) of memory for footshock active avoidance training (FAAT) in weakly trained mice (8).