Anesthetic dose correction in hospital pharmacology using bispectral index monitoring technology
2014
Introduction. Modern hospital pharmacology insists on assessing each
patient’s individual characteristics because of their influence on drug
pharmacokinetics and pharmacodynamic effect. The study was aimed at
evaluating anesthetic doses in patients with benign larynx tumors treated by
general endotracheal anesthesia during endoscopic surgery procedures.
Material and Methods. The study is a part of a prospective, phase IV,
academic study carried out at the Clinical Center of Serbia. The evaluation
included 30 patients, who were divided into two groups: Group A - 10
patients, anesthetized with standard recommended anesthetic doses. The
insight into the obtained bispectral index values was possible only after
completion of the surgery. Group B consisted of 20 patients, anesthetized
with anesthetic doses corrected according to bispectral index monitoring
values. Results. The average duration of waking up in group A and B was 120.0
±10.0 sec and B 70.0±9.0 sec, respectively, (p<0.01). When compared with
group A the corrected induction anesthetic doses, corrected maintenance doses
and anesthetic total consumption were lower in group B by 25% (p<0.01), 15%
(p<0.01) and 25% (p<0.01), respectively. Conclusion. It is possible to
overdose anesthetic drug during surgery without using bispectral index
technology monitoring during general anesthesia in otorhinolaryngology
maxillofacial surgery. Bispectral index monitoring should be the clinical
standard in general anesthesia.
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