Effect of Ultrafiltration on Lung Protection during Cardiopulmonary Bypass in Congenital Heart Diseases

Objective:To observe the effect of lung protection of the ultrafiltration in the patients undergoing congenital heart defect repair during cardiopulmonary bypass(CPB).Methods:Twenty-eight congenital heart defect patients were randomly divided into two groups.In treat- ment group (n=14),ultrafiltration was used during CPB,while in control group (n=14),ultrafiltration was not used.Blood samples were col- lected from central vein,and then hematocrit (HCT),tumour necrosis factor-α(TNFα),c3a,c4a and the airway pressure were measured before CPB,10 min after the aortic declamping or 10min after CPB for control group/10min after modified ultrafiltration(MUF) for ultrafiltration group using the mechainical ventilation.Results:The plasma levels of c3a,c4a,TNFαincreased more significantly in control group than those in treat- ment group.The airway pressure decreased more and HCT increased more in the treated group.There was significant difference in the results of detection between the two groups.Conclusions:The use of ultrafiltration during CPB can inhibit the inflammatory cytokine release,protect the lung function and reduce the postoperative complications.