Medication Use Leading to Hospital Readmission in Frail Elders

Abstract Frail multimorbid elders are at high risk for hospital readmission and can benefit from dedicated care transitions programs. Nonetheless, some patients remain at disproportionately heightened risk. In this retrospective study of 717 frail multimorbid community-dwelling elders (mean age = 83 years) enrolled in a care transitions program, we assessed the effect of specific medications and postdischarge medication changes on 30-day readmission. Patients treated with opioids, anticholinergic agents, or antihistamines and those requiring ≥ 4 medication changes after hospital discharge were at a significantly greater risk. This knowledge provides nurse practitioners an opportunity to individualize and improve the care of this vulnerable population.