Risk factors for TB among household contacts of patients with smear-positive TB in eight provinces of Vietnam: a nested case-control study.

BACKGROUND Tuberculosis (TB) continues to account for significant morbidity and mortality annually. Household contacts (HHCs) of persons with TB are a key population for targeting prevention and control interventions. We aimed to identify risk factors associated with developing TB among HHCs. METHODS We conducted a nested case-control study among HHCs in eight provinces in Vietnam who were enrolled in a randomized control trial of active case finding for TB. Cases were any HHCs diagnosed and registered with TB within the Vietnam National TB programme during two years of follow-up. Controls were selected by simple random sampling from the remaining HHCs. Risk factor data were collected at enrolment and during follow-up. A logistic regression model was developed to determine predictors of TB among HHCs. RESULTS We selected 1,254 HHCs for the analysis; 214 cases and 1,040 controls. Underlying characteristics varied between both groups; cases were older, more likely to be male, higher proportion of reported previous TB and diabetes. Risk factors associated with a TB diagnosis included being male (aOR 1.4; 95% CI: 1.03-2.0), residing in an urban setting (aOR 1.8; 1.3-2.5), prior TB (aOR 4.6; 95% CI: 2.5-8.7), history of diabetes (aOR 3.1; 95% CI: 1.7-5.8), current smoking (aOR 3.1; 95% CI: 2.2-4.4) and prolonged history of coughing in the source case at enrolment (OR 1.6; 95% CI: 1.1-2.3). CONCLUSIONS Household contacts remain and important key population for TB prevention and control. TB programmes should ensure effective contact investigations are implemented for household contacts, particularly those with additional risk factors for developing tuberculosis.