Regioselective Prenylation of Bromocarbazoles by Palladium(0)-Catalyzed Cross Coupling — Synthesis of O-Methylsiamenol, O-Methylmicromeline and Carquinostatin A.

The palladium-catalyzed cross-coupling of bromocarbazoles with tert-prenylboronate (II) proceeds with a complete inversion of the allyl system to provide access to O-methylsiamenol (III), O-methylmicromeline (V), and prenylcarbazole (VII).