One-pot synthesis of triazole-fused isoindoles from o-alkynylbenzaldehydes and trimethylsilyl azide

Abstract An efficient one-pot synthesis of 1,2,3-triazole-fused isoindoles from o -alkynylbenzaldehydes and trimethylsilyl azide (TMSN 3 ) is reported. The reaction proceeds through the formation of a diazide intermediate and a subsequent intramolecular azide-alkyne cycloaddition, providing a novel access to a variety of 8-azido-8 H -[1,2,3]triazolo[5,1- a ]isoindoles in high yields.