Studies Toward the Total Synthesis of Combretastatin D4

Different approaches for the synthesis of Combretastatin D2 have been described, but due to date no synthetic approaches as well as cytotoxicity studies have been reported for Combretastatin D4 (CA-D4). The interest in the design and synthesis of angiogenesis inhibitors prompted us to design a new, convergent route to this class of compounds with a view to further studies of biological properties of the natural product and its analogues.