Study of HLA antigens in familial and sporadic rheumatoid arthritis
2008
Patients with familial and non-familial (sporadic) forms of rheumatoid arthritis (RA) were studied to investigate possible HLA heterogeneity. HLA-DR4 was present in 75% of familial and 59% of sporadic RA patients. The frequency distribution of A2, B8, B27, Cw3 and DR3 differed somewhat between the two groups; however, the differences were not statistically significant in this small group of patients. Studies of a larger number of patients are indicated to explore the possibility of genetic subgroups in RA.
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