Method of controlling the blood kinetics of the antibody

Of the variable region residues of an IgG antibody is a polypeptide comprising an FcRn-binding domain, was found to be controlled serum half-life of IgG antibodies by controlling the residues modified surface charges exposed on the surface . Antibody half-life in blood is controlled by the method of the present invention, it was confirmed that actually retain activity. The method of the present invention, regardless of the type of target antigen, it is widely applicable to polypeptides comprising an FcRn-binding region that is recycled by the salvage pathway for FcRn such as IgG antibodies.