Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study Rapports entre l'anemie preoperatoire, l'anemie peroperatoire et la transfusion de globules rouges vus comme facteurs de risque potentiellement modifiables des lesions renales aigues au cours de la chirurgie cardiaque: une etude de cohorte multicentrique historique

Purpose Acute kidney injury (AKI) is a potentially serious complication of cardiac surgery. Anemia and red blood cell (RBC) transfusion have individually been identified as potentially modifiable risk factors, but their interrelationship with AKI has not been clearly defined. The purpose of this study was to explore the interrelationship of preoperative anemia, intraoperative anemia, and RBC transfusion on the day of surgery with AKI in cardiac surgery. Methods This historical cohort study included 16 hospitals, each contributing data on approximately 100 Authorship contributions All authors have made substantial contributions to the conception and design of the study and to the acquisition and interpretation of data. Keyvan Karkouti conducted the analysis and wrote the first draft of the manuscript. All authors took part in manuscript revision.