Diagnostic sensitivity of three tumour markers in non-small cell lung cancer: a pilot study.
2000
BACKGROUND: Three tumour markers (CEA, CYFRA 21.1 and
CA125) were evaluated for diagnostic sensitivity in newly diagnosed,
untreated non-small cell lung cancer. METHODS: In the 24 patients studied, the tumours were classified
histologically as 15 squamous cell carcinomas and 9
adenocarcinomas. In 19 cases, the disease was confined to
the lung (M0); 5 cases presented with metastatic disease at
the time of diagnosis (M1). RESULTS: CA125 displayed the best overall sensitivity (62%)
and also when only localised disease was evaluated (63%).
CA125 was the most sensitive marker for adenocarcinomas
(89%), with values differing significantly with histological type
(p CONCLUSIONS: This pilot study allows recommendation of the
associated use of these two markers as first choice of diagnostic
aid in non-small cell lung cancer. Further measurements,
including specificity studies in benign lung diseases, should be
performed to confirm these results.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
2
Citations
NaN
KQI