Stereoselective synthesis of novel (R)- and (S)-5-azidomethyl-2-oxazolidinones from (S)-epichlorohydrin: a key precursor for the oxazolidinone class of antibacterial agents

G. Madhusudhan,G. Om Reddy,T. Rajesh,J. Ramanatham,P. K. Dubey

Stereoselective synthesis of novel (R)- and (S)-5-azidomethyl-2-oxazolidinones from (S)-epichlorohydrin: a key precursor for the oxazolidinone class of antibacterial agents

2008

G. Madhusudhan
G. Om Reddy
T. Rajesh
J. Ramanatham
P. K. Dubey

Abstract A facile synthesis of novel ( R )- and ( S )-5-azidomethyl-2-oxazolidinones starting from ( S )-epichlorohydrin is described. The ( R )-azide was utilized for the preparation of Linezolid.

Keywords:

Linezolid
Epichlorohydrin
Chemistry
Organic chemistry
Stereoselectivity

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