4-aromatic aminoquinazoline derivative and purpose thereof

2010 
The invention discloses a 4-aromatic aminoquinazoline derivative and a purpose thereof, wherein the 4-aromatic aminoquinazoline derivative has a structure shown as the formula (I). Pharmacological experiments indicate that the compounds or the pharmaceutically acceptable salts thereof can restrain the multiplication of multiple tumor cells. In the formula, ring A is a benzene ring, an alkylbenzene ring, a benzothiophene ring or an alkyl benzothiophene ring, R1 is hydrogen or alkoxy, n is an integer selected from 1 to 6, R2 is -NR4R5. R4 or R5 is respectively selected from hydrogen, alkyl and naphthenic base, or R4 and R5 are combined to form a substituted or unsubstituted heterolipid ring group, wherein the substituted group is an alkyl or hydroxyalkyl. R3 is an ester group, a substituted or unsubstituted aniline, substituted or unsubstituted pyridine amino, substituted or unsubstituted pyrimidine amino, substituted or unsubstituted benzyl carbamido, substituted or unsubstituted picolyl carbamido, substituted or unsubstituted pyrimidine methyl carbamido or substituted or unsubstituted naphthenic carbamido, wherein the substituted group is halogen, alkyl, phenyl or pyridyl or pyrimidyl, and preferably, the substituted group is phenyl, pyridyl or pyrimidyl.
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