Synthesis and Local Anesthetic Properties of Secondary Alkoxyalkylaminoacylanilides

Abstract Nineteen secondary alkoxyalkylaminoacylanilides were prepared. They were weaker bases and were more hydrophilic than the corresponding analogs lacking the ether function. In 2% solution, these compounds blocked the rat sciatic nerve in vivo after relatively short onset times with good frequency of anesthesia. The duration of block was 0.4–1.5 times that of lidocaine. Their systemic toxicity was low, and their irritation liability in most instances was acceptable.