Oxidative parameters, oxidative DNA damage, and urotensin-II in schizoaffective disorder patients

ABSTRACTOBJECTIVE: Complexity of schizoaffective disorder makes the identification of its pathophysiology a great challenge and there are very limited published data about the role of oxidative stress. Oxidative DNA damage has not been investigated in schizoaffective disorder. Therefore, we aimed to evaluate oxidative DNA damage together with oxidative stress and urotensin-II in patients with schizoaffective disorder.METHODS: Fifty-four patients who were diagnosed as schizoaffective disorder bipolar type (27 of them were in symptomatic remission and 27 of them were not) and 27 healthy volunteers were included in the study. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), and urotensin-II (U-II) levels were calculated and evaluated.RESULTS: TAS and U-II levels were found to be lower in the patient group with and without remission when compared with the control group separately. There were no significant difference in terms...