Intragastric injection for toxicity studies with newborn rats

Abstract The results of this investigation show that the intragastric route of administration provides valid information about the toxic effects of drugs to newborn rats. Differences existing in the responses of young and aged rats to an oral preparation were demonstrated by data obtained from studies in which drugs were given by the intragastric and oral routes. Thus, the technique devised for this study appears to be useful for predicting unusual and unexpected toxicity in infants.