Relationship between neuroendocrine tumor-related symptoms and PROMIS health-related quality-of-life scores.

6109 Background: Neuroendocrine tumors (NETs) can secrete hormones that cause flushing and diarrhea (carcinoid syndrome) and disrupt health-related quality of life (HRQL). The objective of this study was to evaluate the relationship between severity of these symptoms and HRQL. Methods: NET patients were invited via email to participate in an online anonymous survey which consisted of demographics, disease-related questions and two standardized measures of HRQL (RAND-36 and PROMIS-29). PROMIS-29 scores were compared between groups defined by frequency of bowel movements and flushing episodes using analysis of variance. Score differences of 2.5-5.0 points are generally regarded as clinically meaningful. Lower scores on the physical function and social role scales of the PROMIS indicate worse HRQL. Higher scores on other scales indicate worse HRQL. Results: 663 patients participated. 66% were female; 39% were ≥60 years old. Among evaluable cases, 214/637 (34%) reported an average of ≥4 bowel movements per da...