HEMODYNAMIC EFFECTS OF CHRONIC PARTIAL URETERAL OBSTRUCTION (CPUO) IN THE NEWBORN GUINEA PIG

To evaluate the hemodynamic effects of CPUO and reduced renal mass in the neonate, 38 guinea pigs were subjected to left (L) CPUO within the first 48 h of life, 17 of which underwent concurrent right (R) uninephrectomy (NX). Eight sham-operated and 8 NX animals were controls. At 23±2 days of age, L renal blood flow (RBF, ml/min), filtration fraction (FF, %), glcmerular filtration rate (GFR, ml/min) and percent of RBF to the outer third of renal cortex (OCRBF) were measured using microsphere and clearance techniques. Resulting hydronephrosis was variable in animals with CPUO, and each group was divided into Mild and Severe obstruction for ureteral diameter < 3 mm and ≥3 mm respectively. Results were as follows (mean ± SE, *p <0.05 vs Control):