Repeated Δ9-tetrahydrocannabinol exposure in adolescent monkeys: persistent effects selective for spatial working memory.
2014
Adolescent rhesus monkeys administered D9-tetrahydrocannabinol (THC) 5 days a week for 6 months showed less practice-related improvement than unexposed monkeys on a test measuring working memory of spatial relationships. The exposed and unexposed monkeys did not differ in memory of colored objects. The discrepancy between spatial and object memory effects may stem from different developmental trajectories of underlying brain circuits.
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