Preparation and diethylenetriaminepentaacetic acid derivative of diethylenetriaminepentaacetic acid derivative

The present invention relates to a method for preparing intermediate compounds easily and efficiently for the synthesis of gadolinium complex of substituents to improve the retention in and organ specificity blood was introduced, was prepared by the method and to provide a synthetic intermediate. Manufacturing method of diethylenetriaminepentaacetic acid derivative (I) of the present invention comprises the steps reacting a diethylenetriaminepentaacetic acid penta ester and the allyl halide compound; step to remove excess allyl halide compound; and a solvent, diethylenetriaminepentaacetic acid the reaction product of pentaerythritol ester and the allyl halide compound characterized in that it comprises a step of reacting with a base.