Sex, Age and Race Related Normal Values of Right Ventricular Diastolic Function Parameters: Data from the World Alliance of Societies of Echocardiography Study.

ABSTRACT Background Though the assessment of right ventricular (RV) diastolic function is feasible, it has garnered far less momentum for use compared to its left ventricular counterpart. The scarcity of data defining normative RV diastolic function and the fact that implications of RV diastolic dysfunction in different disease states on outcomes are less well known, both hinder integration into routine clinical assessment. We sought to establish normal values of RV diastolic parameters stratified by sex, age and race using data from the World Alliance of Societies of Echocardiography (WASE) Study. Methods We analyzed a subset of 888 normal subjects from the WASE database, including measurements of tricuspid valve (TV) inflow E- and A-wave velocities, E-wave deceleration time, TV annular tissue Doppler e’ and a’ velocities. Additionally, right atrial (RA) maximal volume and RA peak reservoir strain were measured. Patients were grouped by age ( 65 years), and stratified by sex and race. Differences were analyzed using unpaired t-tests. Results When compared to men, women had significantly higher TV e’, E-wave and A-wave velocities, though differences were modest. Increasing age was associated with stepwise lower TV E-wave, e’ velocities and TV E/A, higher a’ velocities and E/e’ ratios. RA peak reservoir strain was also lower and RA ESV trended towards being smaller for older age groups. Asian subjects demonstrated significantly higher a’ velocities, lower E-wave, smallest RA ESV and lowest RA peak strain values, compared to whites of both sexes. Conclusions This study provides normal values for parameters used in the assessment of RV diastolic function stratified by race, sex and age. Our results demonstrate significant differences in RV diastolic parameters between age groups, which manifest in both the individual parameters and composite ratios of TV inflow and annular velocities. While limited sex- and race-related differences were also noted, age appears to have the most significant impact on RV diastolic parameters. These findings may aid in refining the current normative values.