A selective and sensitive voltammetric sensor based on molecularly imprinted polymer for the determination of dipyridamole in pharmaceuticals and biological fluids.

This study introduces a selective and sensitive method for the determination of dipyridamole (DIP) using differential pulse adsorptive stripping voltammetry (DPASV). This method is based on the electrochemical behavior of DIP at a molecularly imprinted polymer (MIP) modified carbon paste electrode. The modified electrode demonstrated a linear response in the range of 1.0-110 ng mL–1 of DIP with a detection limit of 0.05 ng mL–1 under optimal conditions. The proposed method was applied to the DIP determination in tablet and human serum samples and results were satisfying compared with that obtained by HPLC.