Iridium-Catalyzed Asymmetric Borylation of Unactivated Methylene C(sp3)–H Bonds
2019
Herein, we show the highly enantioselective borylation of unactivated methylene C(sp3)–H bonds in 2-alkylpyridines and 2-alkyl-1,3-azole derivatives using an iridium-BINOL-based chiral monophosphite catalyst system. Quantum chemical calculations using the artificial force induced reaction (AFIR) method suggested that a monophosphite-Ir-tris(boryl) complex generates a narrow chiral reaction pocket where the differentiation of the enantiotopic methylene C–H bonds is accomplished through an assembly of multiple noncovalent interactions.
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