Transcranial echoscopy for diagnostic of Parkinson disease: technical constraints and possibilities

Parkinson disease (PD) is one of the most common neurodegenerative disorders. The aim of this study is to review the main pro blems of transcranial echoscopy (TCE) by the pilot clinical investigations and  to analyze opportunities  and possible technical solution s for improvement of diagnostic of Parkinson disease using ultrasound applications. TCE is subjective enough yet, and strongly dependent on experience of physician.  The suggestions for standardization of TCE are presented in this paper. The influence of temporal bone should be taken into account, because defocusing effects of the skull bone drastically decrease the quality of obtained brain images and these distortions are dependent on individual features of a subject.