Synthetic method of (S)-N-Boc-3-hydroxypiperidine

The invention discloses a synthetic method of (S)-N-Boc-3-hydroxypiperidine. The synthetic method comprises: hydrogenating 3-hydroxypyridine to obtain 3-hydroxypiperidine; carrying out heating and refluxing on 3-hydroxypiperidine and a resolving agent namely D-pyroglutamic acid in ethanol solution, and cooling to separate out solids so as to obtain (S)-3-hydroxypiperidine D-pyroglutamate; and adding (S)-3-hydroxypiperidine D-pyroglutamate into di-tert-butyl dicarbonate ester under an alkaline condition, and carrying out refining after reaction to obtain (S)-N-Boc-3-hydroxypiperidine. According to the synthetic method disclosed by the invention, by optimizing a synthetic route of (S)-N-Boc-3-hydroxypiperidine and adopting the low-cost and recyclable resolving agent to reduce the production cost, the yield is improved while ensuring the product purity.