Matrix metalloprotease inhibitors and uses thereof

The present invention provides a new means for inhibiting matrix metalloproteases related to glycosaminoglycan oligosaccharides, and provides a way to treat chronic obstructive pulmonary disease and the like. Hyaluronic acid oligosaccharides, keratan sulfate oligosaccharides, 6-O-sulfated N-acetylheparosan and N, 6-O-sulfated heparosan, and pharmaceutically acceptable glycosaminoglycans thereof Matrix metalloproteinase inhibitor or inhibitor, elastase activity inhibitor, chronic obstructive pulmonary disease therapeutic agent, etc. containing at least one or more selected from the group consisting of oligosaccharide salts as active ingredients It has been found that the above-mentioned problems can be solved by providing them. [Selection figure] None