Effects of vitamin E deficiency and dietary linoleate on serum thromboxane synthesis in male Sprague-Dawley rats

Abstract The aim of the present study was to examine whether vitamin E deficiency and dietary linoleate had additive or synergistic effects on serum thromboxane (TX) status and therefore on thrombogenesis. Eight groups of five male weaning Sprague-Dawley rats were fed semipurified diets containing 3.5 or 18.4% of energy from linoleate (en % linoleate) and 0, 100, 5000, 15 000 ppm vitamin E for 8 weeks. Rats fed no vitamin E had the lowest serum vitamin E while rats fed 15 000 ppm vitamin E had the highest serum vitamin E ( p p 2 , measured as its stable metabolite TXB 2 , was significantly greater in the vitamin E-deficient rats than in the vitamin E-adequate and vitamin E-supplemented rats ( p p