Process for preparation of gemcitabine and associated intermediates.

Process for preparing gemcitabine and associated intermediates. The present invention provides novel intermediate steps, preferably including derivatives of 2,2-difluoro-3-hydroxy-3- (2,2-dialquildioxolan-4-yl) -propionate alkyl substituted in position 3, and derivatives of 2-deoxy-2,2-difluoro-1-oxo-D-ribose disubstituted 3.5. The present invention also provides processes for producing such intermediate steps and processes for producing gemcitabine therefrom.