ATR-FTIR characterization of Janus nanoparticles. Part II: follow-up skin application

Abstract Attenuated total reflection by Fourier transform infrared (ATR-FTIR) was used to implement reliable infrared descriptors over time of Janus nanoparticles (JNP), in order to follow their behavior before and after cutaneous application. In the last study, ATR-FTIR spectroscopic analysis, allowed us to identify the evolution of intensity ratio of ν (C=O) at 1739 cm -1 and δ (H-O-H) at 1639 cm -1 as a spectroscopic descriptor, for JNP before cutaneous application (on the CaF 2 window). This descriptor can be used to follow the physical stability (presence) of nanoparticles over time. The purpose of this study is to understand the behavior of JNP on the surface of human skin. Therefore, a comparative study with the untreated skin and the skin after cutaneous application of lipophilic phase (Labrafil) of JNP was conducted using Franz cells. The suitability of the ATR-FTIR descriptor of JNP was evaluated and a research of other descriptors was performed to understand the interaction that may exist between nanoparticles and the skin.