Synthesis of myo-inositol-1-phosphatase inhibitors in which the phosphate group is replaced by less polar groups
1995
Abstract The phosphate group in the inositol-1-phosphatase inhibitor ( 1 ) is replaced by less polar phosphorus containing groups (substituted phosphate and phosphonates), by sulphur containing substituents (sulphate, sulphonamides) and by a carboxylate and carbamate. The effect of the replacement is studied on the enzyme myo -inositol-1-phosphatase.
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