Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma

Gamma heavy chain disease (gHCD) is defined by an abnormally truncated IgG heavy chain monoclonal protein that lacks associated light chains and is secreted by a small B-cell neoplasm with plasmacytic differentiation.[1][1],[2][2] Clinically, gHCD is associated with a female predominance and a high