The EpiDerm™ Phototoxicity Test (EpiDerm™ H3D-PT)

Assessment of the phototoxicity hazard and phototoxic potency (i.e. phototoxic risk) of topically or systemically applied compounds and mixtures is a crucial step in the safety assessment of cosmetic, pesticide and pharmaceutical products absorbing UV and visible light. The validated and regulatory accepted in vitro assay, the 3T3 NRU PT (OED TG 432), provides high level of sensitivity and thus also protection for the end-users, however, it has been reported that it also generates high rate of false positive results due to the lack of barrier properties naturally appearing in the human skin or other targeted tissues.