Determination of Interleukin- 13 and Interleukin 27 on Schizophrenic Serums

There is increasing evidence suggesting that cytokines abnormalities are involved in the pathogenesis of schizophrenic disorders. The aim of this study was to evaluate the serum levels of interleukin-27 (IL-27) and interleukin-13 (IL-13) in patients with schizophrenia compare to healthy control subjects. In present study the serum IL-27 and IL-13 levels of 38 schizophrenic patients and 32 age and sex matched healthy control subjects using a sandwich ELISA assay was measured. IL-13 serum level were increased significantly in schizophrenic patients compare to healthy control group (4.32 ± 0.94 vs 2.04 ± 0.17, p<0. 01) and a significant increase in female patients (5.2±5.1) and the healthy females (2.05±.21) (p< 0.01) has found. There was also reported a significant increased in IL-13 on male patients (3.63±2.51) and healthy males (2.03±.144) with (p < 0.01). The findings also have been shown that there is a significant difference between the serum level of interleukin-27 of the patient (171) and healthy) group (231) (p < 0.05). There is a significant decrease between IL-27 in male schizophrenic patients compare to healthy controls. However a significant increase was found between IL-13 schizophrenic patients when compare with healthy control. A non-significant difference was reported in male and female in IL-13 schizophrenic patients.