Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease

Lynn W. Maines,Leo R. Fitzpatrick,Cecelia L. Green,Yan Zhuang,Charles D. Smith

Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease

2010

Lynn W. Maines
Leo R. Fitzpatrick
Cecelia L. Green
Yan Zhuang
Charles D. Smith

Aim Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn’s disease.

Keywords:

Biochemistry
Crohn's disease
Inflammatory bowel disease
Disease
Sphingosine kinase
Immunology
Medicine
pharmacology toxicology
Diabetes mellitus
Allergy
Rheumatology
Internal medicine

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