Cell-surface antigens induced by avian RNA tumor viruses: Detection by immunoferritin technique

Abstract By the use of neutralizing chicken serum and of immunoferritin labeling, two kinds of antigens were demonstrated on the surface of chicken cells infected or transformed by avian RNA tumor virus. One of these is type or subgroup specific and is probably identical with virus envelope antigen. It is demonstrable on productively infected cells. The second kind of antigen is restricted to transformed cells and is group specific. It is probably not identical with either of the major virus structural proteins. The study of budding particles with the same technique indicated that the permeation of the virus envelope antigen takes place successively during the budding process.