Validating the Family History Scoring System application to identify Lynch syndrome families

Background The FHSS (a points-based scoring system) was previously used to identify families at high risk of an inherited colorectal cancer syndrome. AM-I (Amsterdam-I) families scored high (≤12), but some scored low (≥8) when scored from unaffected relative’s perspective [1]. The FHSS is being applied to Lynch families (MMR+) and familial colon cancer type X (Type X) to see if the scoring system would yield similar results.